@prefix this: <http://purl.org/np/RAEnVQTNuRN9ZH7YAQLXVmCbWNEC3P200EE44dksnhK50> .
@prefix sub: <http://purl.org/np/RAEnVQTNuRN9ZH7YAQLXVmCbWNEC3P200EE44dksnhK50#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix hp: <http://purl.obolibrary.org/obo/HP_> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ntemplate: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

<http://purl.org/np/RAEnVQTNuRN9ZH7YAQLXVmCbWNEC3P200EE44dksnhK50> a np:Nanopublication;
  np:hasAssertion sub:assertion;
  np:hasProvenance sub:provenance;
  np:hasPublicationInfo sub:pubInfo;
  prov:generatedAtTime "2022-09-16T11:52:59.247176"^^xsd:dateTime;
  prov:wasAttributedTo orcid:0000-0002-1501-1082;
  ntemplate:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .

drugbank:DB00321 a biolink:Drug;
  rdfs:label "Amitriptyline";
  biolink:category biolink:Drug .

<http://purl.obolibrary.org/obo/HP_0012228> a biolink:Disease;
  rdfs:label "Tension-type headache";
  biolink:category biolink:Disease .

sub:association a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
  rdf:object <http://purl.obolibrary.org/obo/HP_0012228>;
  rdf:predicate biolink:treats;
  rdf:subject drugbank:DB00321;
  rdfs:label "Tension-type headache (TTH) is the most common primary headache disorder, with a worldwide lifetime prevalence of 46% to 78%. (...) Amitriptyline is recommended as a first-line drug for prophylaxis. (This is an off-label use of amitriptyline).";
  biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
  biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
  biolink:has_population_context sub:context;
  biolink:publications pmid:30346680;
  biolink:relation <http://purl.obolibrary.org/obo/NCIT_C94303> .

sub:context a biolink:Cohort;
  rdfs:label "adults";
  biolink:category biolink:Cohort .

sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .

sub:sig npx:hasAlgorithm "RSA";
  npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
  npx:hasSignature "kR7uSsp1XC6cQgsh+VZsvbzJ0KixKT92gfFqQvrWOrjLJGau1IBi6hmlW1nzGl3ekI9GMFcObvf9y77XishMxJWkVTQucCy6LZwzkYIBfkMrHbVT0N46NL98Ulrzc7fCxz7TI5UVfjPRu50okHy47o/OWP/EcrBVMWFOk03c6no=";
  npx:hasSignatureTarget <http://purl.org/np/RAEnVQTNuRN9ZH7YAQLXVmCbWNEC3P200EE44dksnhK50> .

<https://w3id.org/biolink/vocab/> pav:version "2.3.0" .