@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix this: <http://purl.org/np/RAI0dpOj_s4yF7teQk5dx6y5h2cx7ReSlJmrCb8haXkOQ> .
@prefix sub: <http://purl.org/np/RAI0dpOj_s4yF7teQk5dx6y5h2cx7ReSlJmrCb8haXkOQ#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

<http://purl.org/np/RAI0dpOj_s4yF7teQk5dx6y5h2cx7ReSlJmrCb8haXkOQ> a np:Nanopublication;
  np:hasAssertion sub:assertion;
  np:hasProvenance sub:provenance;
  np:hasPublicationInfo sub:pubInfo;
  prov:generatedAtTime "2021-08-25T12:27:32.383551"^^xsd:dateTime;
  prov:wasAttributedTo orcid:0000-0002-7641-6446;
  nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .

<http://purl.obolibrary.org/obo/HP_0012228> a bl:Disease .

sub:association a rdf:Statement;
  rdf:object <http://purl.obolibrary.org/obo/HP_0012228>;
  rdf:predicate bl:treats;
  rdf:subject <https://identifiers.org/DRUGBANK:DB00321>;
  rdfs:label "Tension-type headache (TTH) is the most common primary headache disorder, with a worldwide lifetime prevalence of 46% to 78%. (...) Amitriptyline is recommended as a first-line drug for prophylaxis. (This is an off-label use of amitriptyline).";
  bl:has_population_context sub:context;
  bl:provided_by <https://w3id.org/um/NeuroDKG>;
  bl:publications <https://pubmed.ncbi.nlm.nih.gov/30346680>;
  bl:relation nkg:OffLabelIndication .

sub:context a bl:Cohort;
  rdfs:label "adults" .

<https://identifiers.org/DRUGBANK:DB00321> a bl:Drug .

sub:assertion prov:generatedAtTime "2021-08-25T12:27:32.383551"^^xsd:dateTime .

sub:sig npx:hasAlgorithm "RSA";
  npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB";
  npx:hasSignature "NOIOaZCHcx5VTp6R/NF3MvZ3dz6EkjC5yQdYowYHAZ1pNgTnox6pRXxdrOrZ28h6yzV7Gtq3cimHkyeUcDrEjlwSoRGRayT68eWvE8IAkwjtXcMg61j7n6zr9l7u77BjTJ9KYed5RxaO74J5SjbEzN0Ulb5RQ3cRl5t5oKvgb7M=";
  npx:hasSignatureTarget <http://purl.org/np/RAI0dpOj_s4yF7teQk5dx6y5h2cx7ReSlJmrCb8haXkOQ> .