@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAbwIS061zfp3vhExgR0eTbgpdSfzyismcOKDxlkVo21k> .
@prefix sub: <http://purl.org/np/RAbwIS061zfp3vhExgR0eTbgpdSfzyismcOKDxlkVo21k#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

<http://purl.org/np/RAbwIS061zfp3vhExgR0eTbgpdSfzyismcOKDxlkVo21k> a np:Nanopublication;
  np:hasAssertion sub:assertion;
  np:hasProvenance sub:provenance;
  np:hasPublicationInfo sub:pubInfo;
  prov:generatedAtTime "2022-09-16T11:49:04.738316"^^xsd:dateTime;
  prov:wasAttributedTo orcid:0000-0002-1501-1082;
  nt:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .

drugbank:DB00321 a biolink:Drug;
  rdfs:label "Amitriptyline";
  biolink:category biolink:Drug .

<http://purl.obolibrary.org/obo/MONDO_0100081> a biolink:Disease;
  rdfs:label "sleep disorder";
  biolink:category biolink:Disease .

sub:association a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
  rdf:object <http://purl.obolibrary.org/obo/MONDO_0100081>;
  rdf:predicate biolink:treats;
  rdf:subject drugbank:DB00321;
  rdfs:label "Among TCAs, doxepin (sinequan) appears to be best suited for managing insomnia in healthy adults. Doxepin works as a selective antagonist to H(1) receptors, which promote the initiation and maintenance of sleep (Owen, 2009) (Table 2). Ultra-low doses of this drug (< 6 mg per day) significantly improve and sustain both maintenance and duration of sleep (Rojas-Fernandez and Chen, 2014; Weber et al., 2010). Another frequently prescribed TCA is amitriptyline, which as a long-term option is found to be effective for patients with ongoing sleep problems (Everitt et al., 2014; Pagel and Parnes, 2001).";
  biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
  biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
  biolink:has_population_context sub:context;
  biolink:publications pmid:31622593;
  biolink:relation <http://purl.obolibrary.org/obo/NCIT_C94303> .

sub:context a biolink:Cohort;
  rdfs:label "Adults";
  biolink:category biolink:Cohort .

sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .

sub:sig npx:hasAlgorithm "RSA";
  npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
  npx:hasSignature "kOxpJ0a1ll+DkZ5RdcoknJfvuhEGsmNc4LggjXp8a1SwlMR9VQUiM8GU3r//BvCSkg2v9AOzFNRVJdYscxiX77JK5zuAw7d3QcHbsMi5VoG9zFqXoEuwCBXerRUl75nvVIfK5/FMxbf2SZxmUVM6xuz6DdVg2F6g7gTZkDKYzYU=";
  npx:hasSignatureTarget <http://purl.org/np/RAbwIS061zfp3vhExgR0eTbgpdSfzyismcOKDxlkVo21k> .

<https://w3id.org/biolink/vocab/> pav:version "2.3.0" .