association
Full identifier: http://purl.org/np/RApLDKr2tWV2M7VrSbv3mz5ThbAgOJLPPDy-wAvy0S1w8#association
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Minted in Nanopublication
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#association
This association
http://www.w3.org/2000/01/rdf-schema#label
has label
(this is a literal)
"vinblastine sulfate injection is indicated in the palliative treatment of the following i frequently responsive malignancies generalized hodgkin s disease stages iii and iv ann arbor modification of rye staging system lymphocytic lymphoma nodular and diffuse poorly and well differentiated histiocytic lymphoma mycosis fungoides advanced stages advanced carcinoma of the testis kaposi s sarcoma letterer siwe disease histiocytosis x ii less frequently responsive malignancies choriocarcinoma resistant to other chemotherapeutic agents carcinoma of the breast unresponsive to appropriate endocrine surgery and hormonal therapy current principles of chemotherapy for many types of cancer include the concurrent administration of several antineoplastic agents for enhanced therapeutic effect without additive toxicity agents with different dose limiting clinical toxicities and different mechanisms of action are generally selected therefore although vinblastine sulfate is effective as a single agent in the aforementioned indications it is usually administered in combination with other antineoplastic drugs such combination therapy produces a greater percentage of response than does a single agent regimen these principles have been applied for example in the chemotherapy of hodgkin s disease vinblastine sulfate has been shown to be one of the most effective single agents for the treatment of hodgkin s disease advanced hodgkin s disease has also been successfully treated with several multiple drug regimens that included vinblastine sulfate patients who had relapses after treatment with the mopp program mechlorethamine hydrochloride nitrogen mustard vincristine sulfate prednisone and procarbazine have likewise responded to combination drug therapy that included vinblastine sulfate a protocol using cyclophosphamide in place of nitrogen mustard and vinblastine sulfate instead of vincristine sulfate is an alternative therapy for previously untreated patients with advanced hodgkin s disease advanced testicular germinal cell cancers embryonal carcinoma teratocarcinoma and choriocarcinoma are sensitive to vinblastine sulfate alone but better clinical results are achieved when vinblastine sulfate is administered concomitantly with other antineoplastic agents the effect of bleomycin is significantly enhanced if vinblastine sulfate is administered six to eight hours prior to the administration of bleomycin this schedule permits more cells to be arrested during metaphase the stage of the cell cycle in which bleomycin is active"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#subject
has drug
https://identifiers.org/drugbank:DB00570
drugbank:DB00570
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#object
has disease
http://purl.obolibrary.org/obo/DOID_8632
DOID_8632
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#association
This association
https://w3id.org/biolink/vocab/relation
has relation
https://w3id.org/um/neurodkg/SymptomaticReliefIndication
An indication for only managing the symptoms of the condition
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#association
This association
https://w3id.org/biolink/vocab/association_type
has BioLink type
https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation
ChemicalToDiseaseOrPhenotypicFeatureAssociation
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
has type
http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement
association Statement
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate
has predicate
https://w3id.org/biolink/vocab/treats
treats
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#association
This association
https://w3id.org/biolink/vocab/provided_by
is provided by
https://w3id.org/um/NeuroDKG
NeuroDKG
.
This is the identifier for the assertion of this nanopublication.
http://purl.org/np/RApLDKr2tW...#assertion
The assertion above
http://www.w3.org/ns/prov#wasAttributedTo
is attributed to
https://orcid.org/0000-0002-1468-3557
me (Leoni Bücken)
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RApLDKr2tW...
This nanopublication
http://purl.org/dc/terms/creator
is created by
https://orcid.org/0000-0002-1468-3557
me (Leoni Bücken)
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RApLDKr2tW...
This nanopublication
date and time when the nanopublication was created
http://purl.org/dc/terms/created
was created on
(this is a literal)
"2021-06-30T09:21:44.826+02:00"
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RApLDKr2tW...
This nanopublication
links to the assertion template that was used to create this nanopublication
https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate
was created from the assertion template
http://purl.org/np/RAManV5GZI...
RAManV5GZI
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RApLDKr2tW...
This nanopublication
links to the provenance template that was used to create this nanopublication
https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate
was created from the provenance template
http://purl.org/np/RANwQa4ICW...
RANwQa4ICW
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RApLDKr2tW...
This nanopublication
links to the publication info template that was used to create this nanopublication
https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate
was created from the publication info template
http://purl.org/np/RAA2MfqdBC...
RAA2MfqdBC
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#sig
sig
http://purl.org/nanopub/x/hasSignatureTarget
has as target
This is the identifier for this whole nanopublication.
http://purl.org/np/RApLDKr2tW...
this nanopublication
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#sig
sig
http://purl.org/nanopub/x/hasAlgorithm
has the algorithm
(this is a literal)
"RSA"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#sig
sig
http://purl.org/nanopub/x/hasPublicKey
has the public key
(this is a literal)
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RApLDKr2tW...#sig
sig
http://purl.org/nanopub/x/hasSignature
has the signature
(this is a literal)
"hTXdxYvWdxJV7GySQ4WgJ4oN8oQZKJYdLkl8Q2xCYO35PVjCV6akKbVe5dLxmP1tgZ4o/3Jwg5Jds50rXO2kDbLQjpQHw7y/YdjwEP5XTiHM9CmGO+TuByQ7PeuV9esUyf6auOtkQ1N4mcb7j0jxZuFZ8XSEOJO6WK2Sk98Nj8M="
.