http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#subject subject

http://identifiers.org/drugbank/DB00904 DB00904

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#object object

http://purl.obolibrary.org/obo/DOID_1574 DOID_1574

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/aggregator_knowledge_source aggregator_knowledge_source

https://w3id.org/biolink/infores/knowledge-collaboratory knowledge-collaboratory

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/relation relation

http://purl.obolibrary.org/obo/NCIT_C94303 NCIT_C94303

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate predicate

https://w3id.org/biolink/vocab/treats treats

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/has_population_context has_population_context

http://purl.org/np/RA8FelCvPB...#context context

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/category category

https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation ChemicalToDiseaseOrPhenotypicFeatureAssociation

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/2000/01/rdf-schema#label label

While alcohol induces an increase of dopamine, ondansetron reduces the release of the neurotransmitter by blocking the 5-HT3 receptors. Several studies investigated the effectiveness of ondansetron by dividing alcoholic individuals into two subgroups based on their genotype for the promoter region of the SLC6A4 gene coding for the serotonin transporter (5-HTTLPR L/S polymorphism). The study showed that the patients with the LL genotype treated with ondansetron responded better in terms of alcohol amount and days of abstinence, compared to the other subgroups. Based on these results, researchers have further investigated genotype LL carriers, by analyzing the role of a functional polymorphism of the SLC6A4 gene (rs1042173 [T/G] SNP). The result was that individuals who carry both 5-HTTLPR LL polymorphism and rs1042173 TT polymorphism, treated with ondansetron at the dosage of 0.5 mg/die, present a more effective response to the drug. Unfortunately, the sample of this exploratory study was too small to be validated.

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/publications publications

http://www.ncbi.nlm.nih.gov/pubmed/29912214 pubmed/29912214

Vincent Emonet

2022-09-16T11:54:31.167Z

http://purl.org/np/RA8FelCvPB... RA8FelCvPB

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#type type

https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation ChemicalToDiseaseOrPhenotypicFeatureAssociation

Vincent Emonet

2022-09-16T11:54:31.167Z