http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#subject subject

http://identifiers.org/drugbank/DB00334 DB00334

Vincent Emonet

2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#object object

http://purl.obolibrary.org/obo/DOID_1574 DOID_1574

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2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/aggregator_knowledge_source aggregator_knowledge_source

https://w3id.org/biolink/infores/knowledge-collaboratory knowledge-collaboratory

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2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/relation relation

http://purl.obolibrary.org/obo/NCIT_C94303 NCIT_C94303

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2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate predicate

https://w3id.org/biolink/vocab/treats treats

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2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/has_population_context has_population_context

http://purl.org/np/RAJ_wIH5Q8...#context context

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2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/category category

https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation ChemicalToDiseaseOrPhenotypicFeatureAssociation

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2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/2000/01/rdf-schema#label label

Olanzapine was FDA approved for the treatment of schizophrenia and bipolar disorder only. It is an atypical antagonist of D2 and D4 receptors which determines a decrease in craving for alcohol. The DRD4 gene of dopamine presents a VNTR polymorphism, with a number of repetitions that varies from 2 to 11 which allows for the division of individuals in two subgroups: those with a number of repetitions between 2 and 6, classified as DRD4 S and those with more than 7 repetitions, classified as DRD4 L. Association studies between this variation and AUD have showed that individuals who carry the L allele exhibit greater craving after alcohol intake,50. Another study has investigated the association olanzapine-DRD4 showing that olanzapine reduces craving to the L allele carriers only, while no benefits were observed in S allele carriers.

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2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/publications publications

http://www.ncbi.nlm.nih.gov/pubmed/29912214 pubmed/29912214

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2022-09-16T11:54:35.529Z

http://purl.org/np/RAJ_wIH5Q8... RAJ_wIH5Q8

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#type type

https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation ChemicalToDiseaseOrPhenotypicFeatureAssociation

Vincent Emonet

2022-09-16T11:54:35.529Z