assertion
Full identifier: http://purl.org/np/RA8FelCvPBxTggV1kWoWeWpAxMHigoTMJwbaz9-O2_B-g#assertion
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Minted in Nanopublication
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#association
This association
http://www.w3.org/2000/01/rdf-schema#label
has label
(this is a literal)
"While alcohol induces an increase of dopamine, ondansetron reduces the release of the neurotransmitter by blocking the 5-HT3 receptors. Several studies investigated the effectiveness of ondansetron by dividing alcoholic individuals into two subgroups based on their genotype for the promoter region of the SLC6A4 gene coding for the serotonin transporter (5-HTTLPR L/S polymorphism). The study showed that the patients with the LL genotype treated with ondansetron responded better in terms of alcohol amount and days of abstinence, compared to the other subgroups. Based on these results, researchers have further investigated genotype LL carriers, by analyzing the role of a functional polymorphism of the SLC6A4 gene (rs1042173 [T/G] SNP). The result was that individuals who carry both 5-HTTLPR LL polymorphism and rs1042173 TT polymorphism, treated with ondansetron at the dosage of 0.5 mg/die, present a more effective response to the drug. Unfortunately, the sample of this exploratory study was too small to be validated."
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#subject
has drug
http://identifiers.org/drugbank/DB00904
DB00904
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#object
has disease
http://purl.obolibrary.org/obo/DOID_1574
DOID_1574
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#association
This association
https://w3id.org/biolink/vocab/relation
has relation
http://purl.obolibrary.org/obo/NCIT_C94303
NCIT_C94303
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#association
This association
https://w3id.org/biolink/vocab/publications
has publications
http://www.ncbi.nlm.nih.gov/pubmed/29912214
pubmed/29912214
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate
has predicate
https://w3id.org/biolink/vocab/treats
treats
.
http://purl.obolibrary.org/obo/DOID_1574
DOID_1574
http://www.w3.org/2000/01/rdf-schema#label
label
"alcohol use disorder"
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA8FelCvPB...#association
association
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
type
https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation
ChemicalToDiseaseOrPhenotypicFeatureAssociation
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA8FelCvPB...#association
association
https://w3id.org/biolink/vocab/aggregator_knowledge_source
aggregator_knowledge_source
https://w3id.org/biolink/infores/knowledge-collaboratory
knowledge-collaboratory
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA8FelCvPB...#association
association
https://w3id.org/biolink/vocab/category
category
https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation
ChemicalToDiseaseOrPhenotypicFeatureAssociation
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA8FelCvPB...#association
association
https://w3id.org/biolink/vocab/has_population_context
has_population_context
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA8FelCvPB...#context
context
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA8FelCvPB...#context
context
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
type
https://w3id.org/biolink/vocab/Cohort
Cohort
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA8FelCvPB...#context
context
http://www.w3.org/2000/01/rdf-schema#label
label
"adults"
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA8FelCvPB...#context
context
https://w3id.org/biolink/vocab/category
category
https://w3id.org/biolink/vocab/Cohort
Cohort
.
This is the identifier for the assertion of this nanopublication.
http://purl.org/np/RA8FelCvPB...#assertion
The assertion above
http://www.w3.org/ns/prov#wasAttributedTo
wasAttributedTo
https://orcid.org/0000-0002-7641-6446
0000-0002-7641-6446
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RA8FelCvPB...
This nanopublication
links to the assertion template that was used to create this nanopublication
https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate
was created from the assertion template
http://purl.org/np/RAhNHZw6Ur...
RAhNHZw6Ur
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#sig
sig
http://purl.org/nanopub/x/hasSignatureTarget
has as target
This is the identifier for this whole nanopublication.
http://purl.org/np/RA8FelCvPB...
this nanopublication
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#sig
sig
http://purl.org/nanopub/x/hasAlgorithm
has the algorithm
(this is a literal)
"RSA"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#sig
sig
http://purl.org/nanopub/x/hasPublicKey
has the public key
(this is a literal)
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA8FelCvPB...#sig
sig
http://purl.org/nanopub/x/hasSignature
has the signature
(this is a literal)
"Amf2NBNpvSMgD1GnrMQcNJ669LPBQoTJYYwl3ipoapQkPeN8/oq1blWCDCMjt5abhgU+qt3ZKJjPKiZv7ePNUwa5z2K9Qf52NWKRGq3ms8O9ItnTUFqeK8EDwfQGVS5cw2MFhU6HqMUHiBl1uDY83uSaNB4tYCQksQmasx04cjQ="
.
https://w3id.org/biolink/vocab/
vocab
http://purl.org/pav/version
version
(this is a literal)
"2.3.0"
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RA8FelCvPB...
this nanopublication
http://www.w3.org/ns/prov#generatedAtTime
generatedAtTime
(this is a literal)
"2022-09-16T11:54:31.167009"
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RA8FelCvPB...
this nanopublication
http://www.w3.org/ns/prov#wasAttributedTo
wasAttributedTo
https://orcid.org/0000-0002-1501-1082
Vincent Emonet
.
References