assertion
Full identifier: http://purl.org/np/RATNgWiQhWgw2jHben2SchYjls-qwPedJuWyMoC6dUscI#assertion
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Minted in Nanopublication
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#association
This association
http://www.w3.org/2000/01/rdf-schema#label
has label
(this is a literal)
"doxazosin tablets usp are indicated for the treatment of both the urinary outflow obstruction and obstructive and irritative symptoms associated with bph obstructive symptoms hesitation intermittency dribbling weak urinary stream incomplete emptying of the bladder and irritative symptoms nocturia daytime frequency urgency burning doxazosin tablets usp may be used in all bph patients whether hypertensive or normotensive in patients with hypertension and bph both conditions were effectively treated with doxazosin tablets usp monotherapy doxazosin tablets usp provide rapid improvement in symptoms and urinary flow rate in 66 to 71 of patients sustained improvements with doxazosin tablets usp were seen in patients treated for up to 14 weeks in double blind studies and up to 2 years in open label studies doxazosin tablets usp are indicated for the treatment of hypertension to lower blood pressure lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events primarily strokes and myocardial infarctions these benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including this drug control of high blood pressure should be part of comprehensive cardiovascular risk management including as appropriate lipid control diabetes management antithrombotic therapy smoking cessation exercise and limited sodium intake many patients will require more than one drug to achieve blood pressure goals for specific advice on goals and management see published guidelines such as those of the national high blood pressure education program s joint national committee on prevention detection evaluation and treatment of high blood pressure jnc numerous antihypertensive drugs from a variety of pharmacologic classes and with different mechanisms of action have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality and it can be concluded that it is blood pressure reduction and not some other pharmacologic property of the drugs that is largely responsible for those benefits the largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly elevated systolic or diastolic pressure causes increased cardiovascular risk and the absolute risk increase per mmhg is greater at higher blood pressures so that even modest reductions of severe hypertension can provide substantial benefit relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk so the absolute benefit is greater in patients who are at higher risk independent of their hypertension for example patients with diabetes or hyperlipidemia and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal some antihypertensive drugs have smaller blood pressure effects as monotherapy in black patients and many antihypertensive drugs have additional approved indications and effects e g on angina heart failure or diabetic kidney disease these considerations may guide selection of therapy doxazosin tablets usp may be used alone or in combination with diuretics beta adrenergic blocking agents calcium channel blockers or angiotensin converting enzyme inhibitors"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#subject
has drug
https://identifiers.org/drugbank:DB00590
drugbank:DB00590
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#object
has disease
http://purl.obolibrary.org/obo/DOID_10763
DOID_10763
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#association
This association
https://w3id.org/biolink/vocab/relation
has relation
https://schema.org/TreatmentIndication
An indication for treating an underlying condition.
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#association
This association
https://w3id.org/biolink/vocab/association_type
has BioLink type
https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation
ChemicalToDiseaseOrPhenotypicFeatureAssociation
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
has type
http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement
association Statement
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate
has predicate
https://w3id.org/biolink/vocab/treats
treats
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#association
This association
https://w3id.org/biolink/vocab/provided_by
is provided by
https://w3id.org/um/NeuroDKG
NeuroDKG
.
This is the identifier for the assertion of this nanopublication.
http://purl.org/np/RATNgWiQhW...#assertion
The assertion above
http://www.w3.org/ns/prov#wasAttributedTo
is attributed to
https://orcid.org/0000-0002-1468-3557
me (Leoni Bücken)
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RATNgWiQhW...
This nanopublication
http://purl.org/dc/terms/creator
is created by
https://orcid.org/0000-0002-1468-3557
me (Leoni Bücken)
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RATNgWiQhW...
This nanopublication
date and time when the nanopublication was created
http://purl.org/dc/terms/created
was created on
(this is a literal)
"2021-06-12T16:41:31.677+02:00"
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RATNgWiQhW...
This nanopublication
links to the assertion template that was used to create this nanopublication
https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate
was created from the assertion template
http://purl.org/np/RAManV5GZI...
RAManV5GZI
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RATNgWiQhW...
This nanopublication
links to the provenance template that was used to create this nanopublication
https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate
was created from the provenance template
http://purl.org/np/RANwQa4ICW...
RANwQa4ICW
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RATNgWiQhW...
This nanopublication
links to the publication info template that was used to create this nanopublication
https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate
was created from the publication info template
http://purl.org/np/RAA2MfqdBC...
RAA2MfqdBC
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#sig
sig
http://purl.org/nanopub/x/hasSignatureTarget
has as target
This is the identifier for this whole nanopublication.
http://purl.org/np/RATNgWiQhW...
this nanopublication
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#sig
sig
http://purl.org/nanopub/x/hasAlgorithm
has the algorithm
(this is a literal)
"RSA"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#sig
sig
http://purl.org/nanopub/x/hasPublicKey
has the public key
(this is a literal)
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RATNgWiQhW...#sig
sig
http://purl.org/nanopub/x/hasSignature
has the signature
(this is a literal)
"Db6GtptcYsk5VP1ok/8OXQCKGCPfcBZ9wgbH85zDxO3JXdA9w77/slwXTKqlHzl/tFXG/hvoWEOFasOd3YBk5HgAN4Y21sN4WMbC2w53JZQV3HdESG406EAFQ27zLB0lHWUumnx1GRIHBzv89SSqw0Xnmgc6nqkFDzoo0TWleas="
.