sig

Full identifier: http://purl.org/np/RAXELo0q6b-LaEm0dW-pby4P2nn4dLW3Aa_ImvOgR6GYg#sig

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Minted in Nanopublication

 RAXELo0q6b comment approve/disapprove edit as derived nanopublication create new with same template

This is a local identifier minted within the nanopublication. http://purl.org/np/RAXELo0q6b...#association This association http://www.w3.org/2000/01/rdf-schema#label has label (this is a literal) "sotalol hydrochloride tablets usp are indicated for the treatment of documented ventricular arrhythmias such as sustained ventricular tachycardia that in the judgment of the physician are life threatening because of the proarrhythmic effects of sotalol hydrochloride tablets see warnings initiation of sotalol hydrochloride tablet usp treatment or increasing doses as with other antiarrhythmic agents used to treat life threatening arrhythmias should be carried out in the hospital the response to treatment should then be evaluated by a suitable method e g pes or holter monitoring prior to continuing the patient on chronic therapy various approaches have been used to determine the response to antiarrhythmic therapy including sotalol hydrochloride tablets usp in the esvem trial response by holter monitoring was tentatively defined as 1 suppression of ventricular tachycardia 9 suppression of non sustained vt 8 suppression of paired vpcs and 75 suppression of total vpcs in patients who had at least 1 vpcs hour at baseline this tentative response was confirmed if vt lasting 5 or more beats was not observed during treadmill exercise testing using a standard bruce protocol the pes protocol utilized a maximum of three extrastimuli at three pacing cycle lengths and two right ventricular pacing sites response by pes was defined as prevention of induction of the following 1 monomorphic vt lasting over 15 seconds 2 non sustained polymorphic vt containing more than 15 beats of monomorphic vt in patients with a history of monomorphic vt 3 polymorphic vt or vf greater than 15 beats in patients with vf or a history of aborted sudden death without monomorphic vt and 4 two episodes of polymorphic vt or vf of greater than 15 beats in a patient presenting with monomorphic vt sustained vt or nsvt producing hypotension during the final treadmill test was considered a drug failure in a multicenter open label long term study of sotalol hydrochloride tablets usp in patients with life threatening ventricular arrhythmias which had proven refractory to other antiarrhythmic medications response by holter monitoring was defined as in esvem response by pes was defined as non inducibility of sustained vt by at least double extrastimuli delivered at a pacing cycle length of 4 msec overall survival and arrhythmia recurrence rates in this study were similar to those seen in esvem although there was no comparative group to allow a definitive assessment of outcome antiarrhythmic drugs have not been shown to enhance survival in patients with ventricular arrhythmias sotalol is also indicated for the maintenance of normal sinus rhythm delay in time to recurrence of atrial fibrillation atrial flutter afib afl in patients with symptomatic afib afl who are currently in sinus rhythm and is marketed under the brand name betapace af sotalol hydrochloride tablets usp are not approved for the afib afl indication and should not be substituted for betapace af because only betapace af is distributed with a patient package insert that is appropriate for patients with afib afl" .
This is the identifier for this whole nanopublication. http://purl.org/np/RAXELo0q6b... This nanopublication date and time when the nanopublication was created http://purl.org/dc/terms/created was created on (this is a literal) "2021-07-03T11:35:14.650+02:00" .
This is the identifier for this whole nanopublication. http://purl.org/np/RAXELo0q6b... This nanopublication links to the assertion template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate was created from the assertion template http://purl.org/np/RAManV5GZI... RAManV5GZI .
This is the identifier for this whole nanopublication. http://purl.org/np/RAXELo0q6b... This nanopublication links to the provenance template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate was created from the provenance template http://purl.org/np/RANwQa4ICW... RANwQa4ICW .
This is the identifier for this whole nanopublication. http://purl.org/np/RAXELo0q6b... This nanopublication links to the publication info template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate was created from the publication info template http://purl.org/np/RAA2MfqdBC... RAA2MfqdBC .
This is a local identifier minted within the nanopublication. http://purl.org/np/RAXELo0q6b...#sig sig http://purl.org/nanopub/x/hasSignatureTarget has as target This is the identifier for this whole nanopublication. http://purl.org/np/RAXELo0q6b... this nanopublication .
This is a local identifier minted within the nanopublication. http://purl.org/np/RAXELo0q6b...#sig sig http://purl.org/nanopub/x/hasAlgorithm has the algorithm (this is a literal) "RSA" .

Leoni Bücken, 3 Jul 2021, 09:35:14 UTC

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