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sig

Full identifier: http://purl.org/np/RAYiQ_XN8D2NiEG_nswWXZA-eXYSsgC14480c-Gvr_FVI#sig

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Minted in Nanopublication

RAYiQ_XN8D label comment approve/disapprove edit as derived nanopublication

https://w3id.org/biolink/vocab/actively_involved_in actively_involved_in http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "actively involved in - holds between a continuant and a process or function, where the continuant actively contributes to part or all of the process or function it realizes" .

https://w3id.org/biolink/vocab/affected_by affected_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "affected by - describes an entity of which the state or quality is affected by another existing entity." .

https://w3id.org/biolink/vocab/affects affects http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "affects - describes an entity that has a direct affect on the state or quality of another existing entity. Use of the 'affects' predicate implies that the affected entity already exists, unlike predicates such as 'affects risk for' and 'prevents, where the outcome is something that may or may not come to be." .

https://w3id.org/biolink/vocab/affects_risk_for affects_risk_for http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "affects risk for - holds between two entities where exposure to one entity alters the chance of developing the other" .

https://w3id.org/biolink/vocab/ameliorates ameliorates http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "ameliorates - A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure, clinical intervention) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition." .

https://w3id.org/biolink/vocab/assesses assesses http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "assesses - The effect of a thing on a target was interrogated in some assay. A relationship between some perturbing agent (usually a chemical compound) and some target entity, where the affect of the perturbing agent on the target entity was interrogated in a particular assay. The target might be a particular protein, tissue, phenotype, whole organism, cell line, or other type of biological entity." .

https://w3id.org/biolink/vocab/associated_with associated_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "associated with - Expresses a relationship between two named things where the relationship is typically generated statistically (though not in all cases), and is weaker than its child, 'correlated with', but stronger than its parent, 'related to'. This relationship holds between two concepts represented by variables for which a statistical dependence is demonstrated. E.g. the statement “Atrial Fibrillation (Afib) is associated with Myocardial Infarction (MI)” asserts that having Afib is not statistically independent from whether a patient will also have MI. Note that in Translator associations, the subject and object concepts may map exactly to the statistical variables, or represent related entities for which the variables serve as proxies in an Association (e.g. diseases, chemical entities or processes)." .

https://w3id.org/biolink/vocab/associated_with_decreased_likelihood_of associated_with_decreased_likelihood_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "associated with decreased likelihood of - Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is less probable." .

https://w3id.org/biolink/vocab/associated_with_increased_likelihood_of associated_with_increased_likelihood_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "associated with increased likelihood of - Expresses a relationship between two named things where the relationship is typically generated statistically and the state or fact of something is more probable." .

https://w3id.org/biolink/vocab/associated_with_likelihood_of associated_with_likelihood_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "associated with likelihood of - A a relationship that holds between two concepts represented by variables for which a statistical dependence is demonstrated, wherein the state or value of one variable predicts the future state or value of the other. E.g. the statement “An Atrial Fibrillation (Afib) diagnosis is associated with likelihood of a Myocardial Infarction (MI) diagnosis” asserts that the state of having Afib is associated with an increased or decreased likelihood that a patient will later exhibit MI." .

https://w3id.org/biolink/vocab/associated_with_resistance_to associated_with_resistance_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "associated with resistance to - A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of resistance to treatment by the chemical." .

https://w3id.org/biolink/vocab/associated_with_sensitivity_to associated_with_sensitivity_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "associated with sensitivity to - A relation that holds between a named thing and a chemical that specifies that the change in the named thing is found to be associated with the degree of sensitivity to treatment by the chemical." .

https://w3id.org/biolink/vocab/author author http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "author - an instance of one (co-)creator primarily responsible for a written work" .

https://w3id.org/biolink/vocab/binds binds http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "binds - A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction." .

https://w3id.org/biolink/vocab/biomarker_for biomarker_for http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "biomarker for - holds between a measurable chemical entity and a disease or phenotypic feature, where the entity is used as an indicator of the presence or state of the disease or feature." .

https://w3id.org/biolink/vocab/broad_match broad_match http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "broad match - a list of terms from different schemas or terminology systems that have a broader, more general meaning. Broader terms are typically shown as parents in a hierarchy or tree." .

https://w3id.org/biolink/vocab/capable_of capable_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "capable of - holds between a physical entity and process or function, where the continuant alone has the ability to carry out the process or function." .

https://w3id.org/biolink/vocab/caused_by caused_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "caused by - holds between two entities where the occurrence, existence, or activity of one is caused by the occurrence or generation of the other" .

https://w3id.org/biolink/vocab/causes causes http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "causes - holds between two entities where the occurrence, existence, or activity of one causes the occurrence or generation of the other" .

https://w3id.org/biolink/vocab/chemically_similar_to chemically_similar_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "chemically similar to - holds between one small molecule entity and another that it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." .

https://w3id.org/biolink/vocab/close_match close_match http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "close match - a list of terms from different schemas or terminology systems that have a semantically similar but not strictly equivalent, broader, or narrower meaning. Such terms often describe the same general concept from different ontological perspectives (e.g. drug as a type of chemical entity versus drug as a type of role borne by a chemical entity)." .

https://w3id.org/biolink/vocab/coexists_with coexists_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "coexists with - holds between two entities that are co-located in the same aggregate object, process, or spatio-temporal region" .

https://w3id.org/biolink/vocab/coexpressed_with coexpressed_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "coexpressed with - holds between any two genes or gene products, in which both are generally expressed within a single defined experimental context." .

https://w3id.org/biolink/vocab/colocalizes_with colocalizes_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "colocalizes with - holds between two entities that are observed to be located in the same place." .

https://w3id.org/biolink/vocab/composed_primarily_of composed_primarily_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "composed primarily of - x composed_primarily_of_y if:more than half of the mass of x is made from parts of y." .

https://w3id.org/biolink/vocab/condition_associated_with_gene condition_associated_with_gene http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "condition associated with gene - holds between a gene and a disease or phenotypic feature that may be influenced, contribute to, or be correlated with the gene or its alleles/products" .

https://w3id.org/biolink/vocab/contraindicated_for contraindicated_for http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "contraindicated for - Holds between a drug and a disease or phenotype, such that a person with that disease should not be treated with the drug." .

https://w3id.org/biolink/vocab/contributes_to contributes_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "contributes to - holds between two entities where the occurrence, existence, or activity of one causes or contributes to the occurrence or generation of the other" .

https://w3id.org/biolink/vocab/correlated_with correlated_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "correlated with - A relationship that holds between two concepts represented by variables for which a statistical dependence is demonstrated using a correlation analysis method." .

https://w3id.org/biolink/vocab/decreased_likelihood_associated_with decreased_likelihood_associated_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "decreased likelihood associated with - " .

https://w3id.org/biolink/vocab/decreases_amount_or_activity_of decreases_amount_or_activity_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "decreases amount or activity of - A grouping mixin to help with searching for all the predicates that decrease the amount or activity of the object." .

https://w3id.org/biolink/vocab/decreases_response_to decreases_response_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "decreases response to - holds between two chemical entities where the action or effect of one decreases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" .

https://w3id.org/biolink/vocab/derives_from derives_from http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "derives from - holds between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" .

https://w3id.org/biolink/vocab/derives_into derives_into http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "derives into - holds between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" .

https://w3id.org/biolink/vocab/diagnoses diagnoses http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "diagnoses - a relationship that identifies the nature of (an illness or other problem) by examination of the symptoms." .

https://w3id.org/biolink/vocab/directly_physically_interacts_with directly_physically_interacts_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "directly physically interacts with - A causal mechanism mediated by a direct contact between the effector and target entities (this contact may be weak or strong, transient or stable)." .

https://w3id.org/biolink/vocab/disease_has_basis_in disease_has_basis_in http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "disease has basis in - A relation that holds between a disease and an entity where the state of the entity has contribution to the disease." .

https://w3id.org/biolink/vocab/disease_has_location disease_has_location http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "disease has location - A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity." .

https://w3id.org/biolink/vocab/disrupted_by disrupted_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "disrupted by - describes a relationship where the structure, function, or occurrence of one entity is degraded or interfered with by another." .

https://w3id.org/biolink/vocab/disrupts disrupts http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "disrupts - describes a relationship where one entity degrades or interferes with the structure, function, or occurrence of another." .

https://w3id.org/biolink/vocab/editor editor http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "editor - editor of a compiled work such as a book or a periodical (newspaper or an academic journal). Note that in the case of publications which have a containing "published in" node property, the editor association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the editorial agent of the encompassing publication (e.g. only from the Book referenced by the 'published_in' property of a book chapter Publication node)." .

https://w3id.org/biolink/vocab/enabled_by enabled_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "enabled by - holds between a process and a physical entity, where the physical entity executes the process" .

https://w3id.org/biolink/vocab/enables enables http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "enables - holds between a physical entity and a process, where the physical entity executes the process" .

https://w3id.org/biolink/vocab/exacerbates exacerbates http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "exacerbates - A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition." .

https://w3id.org/biolink/vocab/exact_match exact_match http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "exact match - holds between two entities that have strictly equivalent meanings, with a high degree of confidence" .

https://w3id.org/biolink/vocab/expressed_in expressed_in http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "expressed in - holds between a gene or gene product and an anatomical entity in which it is expressed" .

https://w3id.org/biolink/vocab/expresses expresses http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "expresses - holds between an anatomical entity and gene or gene product that is expressed there" .

https://w3id.org/biolink/vocab/food_component_of food_component_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "food component of - holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .

https://w3id.org/biolink/vocab/gene_associated_with_condition gene_associated_with_condition http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "gene associated with condition - holds between a gene and a disease or phenotypic feature that the gene or its alleles/products may influence, contribute to, or correlate with" .

https://w3id.org/biolink/vocab/gene_fusion_with gene_fusion_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "gene fusion with - holds between two independent genes that have fused through translocation, interstitial deletion, or chromosomal inversion to form a new, hybrid gene. Fusion genes are often implicated in various neoplasms and cancers." .

https://w3id.org/biolink/vocab/gene_product_of gene_product_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "gene product of - definition x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of thatf process is either y or something that is ribosomally translated from x" .

https://w3id.org/biolink/vocab/genetic_association genetic_association http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "genetic association - Co-occurrence of a certain allele of a genetic marker and the phenotype of interest in the same individuals at above-chance level" .

https://w3id.org/biolink/vocab/genetic_neighborhood_of genetic_neighborhood_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "genetic neighborhood of - holds between two genes located nearby one another on a chromosome. " .

https://w3id.org/biolink/vocab/genetically_interacts_with genetically_interacts_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "genetically interacts with - holds between two genes whose phenotypic effects are dependent on each other in some way - such that their combined phenotypic effects are the result of some interaction between the activity of their gene products. Examples include epistasis and synthetic lethality." .

https://w3id.org/biolink/vocab/has_active_ingredient has_active_ingredient http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has active ingredient - holds between a drug and a molecular entity in which the latter is a part of the former, and is a biologically active component" .

https://w3id.org/biolink/vocab/has_adverse_event has_adverse_event http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has adverse event - An untoward medical occurrence in a patient or clinical investigation subject that happens during treatment with a therapeutic agent. Adverse events may be caused by something other than the drug or therapy being given and may include abnormal laboratory finding, symptoms, or diseases temporally associated with the treatment, whether or not considered related to the treatment. Adverse events are unintended effects that occur when a medication is administered correctly." .

https://w3id.org/biolink/vocab/has_biomarker has_biomarker http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has biomarker - holds between a disease or phenotypic feature and a measurable chemical entity that is used as an indicator of the presence or state of the disease or feature. # metabolite" .

https://w3id.org/biolink/vocab/has_chemical_role has_chemical_role http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has chemical role - A role is particular behaviour which a chemical entity may exhibit." .

https://w3id.org/biolink/vocab/has_completed has_completed http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has completed - holds between an entity and a process that the entity is capable of and has completed" .

https://w3id.org/biolink/vocab/has_excipient has_excipient http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has excipient - holds between a drug and a molecular entities in which the latter is a part of the former, and is a biologically inactive component" .

https://w3id.org/biolink/vocab/has_food_component has_food_component http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has food component - holds between food and one or more chemical entities composing it, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .

https://w3id.org/biolink/vocab/has_gene_product has_gene_product http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has gene product - holds between a gene and a transcribed and/or translated product generated from it" .

https://w3id.org/biolink/vocab/has_input has_input http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has input - holds between a process and a continuant, where the continuant is an input into the process" .

https://w3id.org/biolink/vocab/has_member has_member http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has member - Defines a mereological relation between a collection and an item." .

https://w3id.org/biolink/vocab/has_metabolite has_metabolite http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has metabolite - holds between two molecular entities in which the second one is derived from the first one as a product of metabolism" .

https://w3id.org/biolink/vocab/has_mode_of_inheritance has_mode_of_inheritance http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has mode of inheritance - Relates a disease or phenotypic feature to its observed genetic segregation and assumed associated underlying DNA manifestation (i.e. autosomal, sex or mitochondrial chromosome)." .

https://w3id.org/biolink/vocab/has_molecular_consequence has_molecular_consequence http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has molecular consequence - connects a sequence variant to a class describing the molecular consequence. E.g. SO:0001583" .

https://w3id.org/biolink/vocab/has_not_completed has_not_completed http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has not completed - holds between an entity and a process that the entity is capable of, but has not completed" .

https://w3id.org/biolink/vocab/has_nutrient has_nutrient http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has nutrient - one or more nutrients which are growth factors for a living organism" .

https://w3id.org/biolink/vocab/has_output has_output http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has output - holds between a process and a continuant, where the continuant is an output of the process" .

https://w3id.org/biolink/vocab/has_part has_part http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has part - holds between wholes and their parts (material entities or processes)" .

https://w3id.org/biolink/vocab/has_participant has_participant http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has participant - holds between a process and a continuant, where the continuant is somehow involved in the process" .

https://w3id.org/biolink/vocab/has_phenotype has_phenotype http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has phenotype - holds between a biological entity and a phenotype, where a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). In SNOMEDCT, disorders with keyword 'characterized by' should translate into this predicate." .

https://w3id.org/biolink/vocab/has_plasma_membrane_part has_plasma_membrane_part http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has plasma membrane part - Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." .

https://w3id.org/biolink/vocab/has_sequence_location has_sequence_location http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has sequence location - holds between two nucleic acid entities when the subject can be localized in sequence coordinates on the object. For example, between an exon and a chromosome/contig." .

https://w3id.org/biolink/vocab/has_side_effect has_side_effect http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has side effect - An unintended, but predictable, secondary effect shown to be correlated with a therapeutic agent, drug or treatment. Side effects happen at normal, recommended doses or treatments, and are unrelated to the intended purpose of the medication." .

https://w3id.org/biolink/vocab/has_variant_part has_variant_part http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "has variant part - holds between a nucleic acid entity and a nucleic acid entity that is a sub-component of it" .

https://w3id.org/biolink/vocab/homologous_to homologous_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "homologous to - holds between two biological entities that have common evolutionary origin" .

https://w3id.org/biolink/vocab/in_cell_population_with in_cell_population_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "in cell population with - holds between two genes or gene products that are expressed in the same cell type or population" .

https://w3id.org/biolink/vocab/in_complex_with in_complex_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "in complex with - holds between two genes or gene products that are part of (or code for products that are part of) in the same macromolecular complex" .

https://w3id.org/biolink/vocab/in_linkage_disequilibrium_with in_linkage_disequilibrium_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "in linkage disequilibrium with - holds between two sequence variants, the presence of which are correlated in a population" .

https://w3id.org/biolink/vocab/in_pathway_with in_pathway_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "in pathway with - holds between two genes or gene products that are part of in the same biological pathway" .

https://w3id.org/biolink/vocab/in_taxon in_taxon http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "in taxon - connects an entity to its taxonomic classification. Only certain kinds of entities can be taxonomically classified; see 'thing with taxon'" .

https://w3id.org/biolink/vocab/increased_likelihood_associated_with increased_likelihood_associated_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "increased likelihood associated with - " .

https://w3id.org/biolink/vocab/increases_amount_or_activity_of increases_amount_or_activity_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "increases amount or activity of - A grouping mixin to help with searching for all the predicates that increase the amount or activity of the object." .

https://w3id.org/biolink/vocab/increases_response_to increases_response_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "increases response to - holds between two chemical entities where the action or effect of one increases the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) to the other" .

https://w3id.org/biolink/vocab/interacts_with interacts_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "interacts with - holds between any two entities that directly or indirectly interact with each other" .

https://w3id.org/biolink/vocab/is_active_ingredient_of is_active_ingredient_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is active ingredient of - holds between a molecular entity and a drug, in which the former is a part of the latter, and is a biologically active component" .

https://w3id.org/biolink/vocab/is_excipient_of is_excipient_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is excipient of - holds between a molecular entity and a drug in which the former is a part of the latter, and is a biologically inactive component" .

https://w3id.org/biolink/vocab/is_frameshift_variant_of is_frameshift_variant_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is frameshift variant of - holds between a sequence variant and a gene, such the sequence variant causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three." .

https://w3id.org/biolink/vocab/is_metabolite_of is_metabolite_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is metabolite of - holds between two molecular entities in which the first one is derived from the second one as a product of metabolism" .

https://w3id.org/biolink/vocab/is_missense_variant_of is_missense_variant_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is missense variant of - holds between a gene and a sequence variant, such the sequence variant results in a different amino acid sequence but where the length is preserved." .

https://w3id.org/biolink/vocab/is_nearby_variant_of is_nearby_variant_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is nearby variant of - holds between a sequence variant and a gene sequence that the variant is genomically close to." .

https://w3id.org/biolink/vocab/is_non_coding_variant_of is_non_coding_variant_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is non coding variant of - holds between a sequence variant and a gene, where the variant does not affect the coding sequence" .

https://w3id.org/biolink/vocab/is_nonsense_variant_of is_nonsense_variant_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is nonsense variant of - holds between a sequence variant and a gene, such the sequence variant results in a premature stop codon" .

https://w3id.org/biolink/vocab/is_sequence_variant_of is_sequence_variant_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is sequence variant of - holds between a sequence variant and a nucleic acid entity" .

https://w3id.org/biolink/vocab/is_splice_site_variant_of is_splice_site_variant_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is splice site variant of - holds between a sequence variant and a gene, such the sequence variant is in the canonical splice site of one of the gene's exons." .

https://w3id.org/biolink/vocab/is_synonymous_variant_of is_synonymous_variant_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "is synonymous variant of - holds between a sequence variant and a gene, such the sequence variant is in the coding sequence of the gene, but results in the same amino acid sequence" .

https://w3id.org/biolink/vocab/likelihood_associated_with likelihood_associated_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "likelihood associated with - " .

https://w3id.org/biolink/vocab/located_in located_in http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "located in - holds between a material entity and a material entity or site within which it is located (but of which it is not considered a part)" .

https://w3id.org/biolink/vocab/location_of location_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "location of - holds between material entity or site and a material entity that is located within it (but not considered a part of it)" .

https://w3id.org/biolink/vocab/manifestation_of manifestation_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "manifestation of - that part of a phenomenon which is directly observable or visibly expressed, or which gives evidence to the underlying process; used in SemMedDB for linking things like dysfunctions and processes to some disease or syndrome" .

https://w3id.org/biolink/vocab/member_of member_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "member of - Defines a mereological relation between a item and a collection." .

https://w3id.org/biolink/vocab/mentioned_by mentioned_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "mentioned by - refers to is a relation between one named thing and the information content entity that it makes reference to." .

https://w3id.org/biolink/vocab/mentions mentions http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "mentions - refers to is a relation between one information content entity and the named thing that it makes reference to." .

https://w3id.org/biolink/vocab/model_of model_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "model of - holds between a thing and some other thing it approximates for purposes of scientific study, in virtue of its exhibiting similar features of the studied entity." .

https://w3id.org/biolink/vocab/molecular_activity_enabled_by molecular_activity_enabled_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "molecular activity enabled by - The gene product, gene, or complex that catalyzes the reaction" .

https://w3id.org/biolink/vocab/molecular_activity_has_input molecular_activity_has_input http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "molecular activity has input - A chemical entity that is the input for the reaction" .

https://w3id.org/biolink/vocab/molecular_activity_has_output molecular_activity_has_output http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "molecular activity has output - A chemical entity that is the output for the reaction" .

https://w3id.org/biolink/vocab/narrow_match narrow_match http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "narrow match - a list of terms from different schemas or terminology systems that have a narrower, more specific meaning. Narrower terms are typically shown as children in a hierarchy or tree." .

https://w3id.org/biolink/vocab/negatively_correlated_with negatively_correlated_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "negatively correlated with - A relationship that holds between two concepts represented by variables for which a statistical correlation is demonstrated, wherein variable values move in opposite directions (i.e. increased in one or presence of one correlates with a decrease or absence of the other)." .

https://w3id.org/biolink/vocab/nutrient_of nutrient_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "nutrient of - holds between a one or more chemical entities present in food, irrespective of nutritional value (i.e. could also be a contaminant or additive)" .

https://w3id.org/biolink/vocab/occurs_in occurs_in http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "occurs in - holds between a process and a material entity or site within which the process occurs" .

https://w3id.org/biolink/vocab/occurs_together_in_literature_with occurs_together_in_literature_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "occurs together in literature with - holds between two entities where their co-occurrence is correlated by counts of publications in which both occur, using some threshold of occurrence as defined by the edge provider." .

https://w3id.org/biolink/vocab/opposite_of opposite_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "opposite of - x is the opposite of y if there exists some distance metric M, and there exists no z such as M(x,z) <= M(x,y) or M(y,z) <= M(y,x). (This description is from RO. Needs to be rephrased)." .

https://w3id.org/biolink/vocab/orthologous_to orthologous_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "orthologous to - a homology relationship between entities (typically genes) that diverged after a speciation event." .

https://w3id.org/biolink/vocab/overlaps overlaps http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "overlaps - holds between entities that overlap in their extents (materials or processes)" .

https://w3id.org/biolink/vocab/paralogous_to paralogous_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "paralogous to - a homology relationship that holds between entities (typically genes) that diverged after a duplication event." .

https://w3id.org/biolink/vocab/part_of part_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "part of - holds between parts and wholes (material entities or processes)" .

https://w3id.org/biolink/vocab/participates_in participates_in http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "participates in - holds between a continuant and a process, where the continuant is somehow involved in the process" .

https://w3id.org/biolink/vocab/physically_interacts_with physically_interacts_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "physically interacts with - holds between two entities that make physical contact as part of some interaction. does not imply a causal relationship." .

https://w3id.org/biolink/vocab/positively_correlated_with positively_correlated_with http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "positively correlated with - A relationship that holds between two concepts represented by variables for which a statistical correlation is demonstrated, wherein variable values move together in the same direction (i.e. increased in one or presence of one correlates with an increase or presence of the other)." .

https://w3id.org/biolink/vocab/preceded_by preceded_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "preceded by - holds between two processes, where the other is completed before the one begins" .

https://w3id.org/biolink/vocab/precedes precedes http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "precedes - holds between two processes, where one completes before the other begins" .

https://w3id.org/biolink/vocab/predisposes predisposes http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "predisposes - holds between two entities where exposure to one entity increases the chance of developing the other" .

https://w3id.org/biolink/vocab/prevented_by prevented_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "prevented by - holds between a potential outcome of which the likelihood was reduced by the application or use of an entity." .

https://w3id.org/biolink/vocab/prevents prevents http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "prevents - holds between an entity whose application or use reduces the likelihood of a potential outcome. Typically used to associate a chemical entity, exposure, activity, or medical intervention that can prevent the onset a disease or phenotypic feature." .

https://w3id.org/biolink/vocab/produces produces http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "produces - holds between a material entity and a product that is generated through the intentional actions or functioning of the material entity" .

https://w3id.org/biolink/vocab/provider provider http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "provider - person, group, organization or project that provides a piece of information (e.g. a knowledge association)." .

https://w3id.org/biolink/vocab/publisher publisher http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "publisher - organization or person responsible for publishing books, periodicals, podcasts, games or software. Note that in the case of publications which have a containing "published in" node property, the publisher association may not be attached directly to the embedded child publication, but only made in between the parent's publication node and the publisher agent of the encompassing publication (e.g. only from the Journal referenced by the 'published_in' property of an journal article Publication node)." .

https://w3id.org/biolink/vocab/regulates regulates http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "regulates - A more specific form of affects, that implies the effect results from a biologically evolved control mechanism. Gene-affects-gene relationships will (almost) always involve regulation. Exogenous/environmental chemical-affects-gene relationships are not cases of regulation in this definition. Instead these would be captured using the 'affects' predicate, or possibly one of the 'interacts with' predicates depending on the nature of the interaction." .

https://w3id.org/biolink/vocab/related_to related_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "related to - A relationship that is asserted between two named things" .

https://w3id.org/biolink/vocab/related_to_at_concept_level related_to_at_concept_level http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "related to at concept level - Represents a relationship held between terminology components that describe the conceptual model of a domain." .

https://w3id.org/biolink/vocab/related_to_at_instance_level related_to_at_instance_level http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "related to at instance level - Represents a relationship held between two instances of a data classes. Much like an assertion component, in an ABox, these represent facts associated with the conceptual model." .

https://w3id.org/biolink/vocab/response_affected_by response_affected_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "response affected by - holds between two chemical entities where the susceptibility of a biological entity or system (e.g. an organism, cell, cellular component, macromolecular machine mixin, biological or pathological process) of one is affected by the action of the other." .

https://w3id.org/biolink/vocab/same_as same_as http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "same as - holds between two entities that are considered equivalent to each other" .

https://w3id.org/biolink/vocab/similar_to similar_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "similar to - holds between an entity and some other entity with similar features." .

https://w3id.org/biolink/vocab/subclass_of subclass_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "subclass of - holds between two classes where the domain class is a specialization of the range class" .

https://w3id.org/biolink/vocab/superclass_of superclass_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "superclass of - holds between two classes where the domain class is a super class of the range class" .

https://w3id.org/biolink/vocab/target_for target_for http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "target for - A gene is a target of a disease when its products are druggable and when a drug interaction with the gene product could have a therapeutic effect" .

https://w3id.org/biolink/vocab/temporally_related_to temporally_related_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "temporally related to - holds between two entities with a temporal relationship" .

https://w3id.org/biolink/vocab/transcribed_from transcribed_from http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "transcribed from - x is transcribed from y if and only if x is synthesized from template y" .

https://w3id.org/biolink/vocab/transcribed_to transcribed_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "transcribed to - inverse of transcribed from" .

https://w3id.org/biolink/vocab/translates_to translates_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "translates to - x (amino acid chain/polypeptide) is the ribosomal translation of y (transcript) if and only if a ribosome reads y (transcript) through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces x (amino acid chain/polypeptide)" .

https://w3id.org/biolink/vocab/translation_of translation_of http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "translation of - inverse of translates to" .

https://w3id.org/biolink/vocab/treated_by treated_by http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "treated by - holds between a disease or phenotypic feature and a therapeutic process or chemical entity that is used to treat the condition" .

https://w3id.org/biolink/vocab/treats treats http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "treats - holds between a therapeutic procedure or chemical entity and a disease or phenotypic feature that it is used to treat" .

https://w3id.org/biolink/vocab/xenologous_to xenologous_to http://www.w3.org/2000/01/rdf-schema#label label (this is a literal) "xenologous to - a homology relationship characterized by an interspecies (horizontal) transfer since the common ancestor." .

This is the identifier for the assertion of this nanopublication. http://purl.org/np/RAYiQ_XN8D...#assertion The assertion above http://www.w3.org/ns/prov#wasDerivedFrom wasDerivedFrom https://raw.githubusercontent....model/master/biolink-model.ttl biolink-model.ttl .

This is a local identifier minted within the nanopublication. http://purl.org/np/RAYiQ_XN8D...#sig sig http://purl.org/nanopub/x/hasSignatureTarget has as target This is the identifier for this whole nanopublication. http://purl.org/np/RAYiQ_XN8D... this nanopublication .

This is a local identifier minted within the nanopublication. http://purl.org/np/RAYiQ_XN8D...#sig sig http://purl.org/nanopub/x/hasAlgorithm has the algorithm (this is a literal) "RSA" .

This is a local identifier minted within the nanopublication. http://purl.org/np/RAYiQ_XN8D...#sig sig http://purl.org/nanopub/x/hasPublicKey has the public key (this is a literal) "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCwUtewGCpT5vIfXYE1bmf/Uqu1ojqnWdYxv+ySO80ul8Gu7m8KoyPAwuvaPj0lvPtHrg000qMmkxzKhYknEjq8v7EerxZNYp5B3/3+5ZpuWOYAs78UnQVjbHSmDdmryr4D4VvvNIiUmd0yxci47dTFUj4DvfHnGd6hVe5+goqdcwIDAQAB" .

This is a local identifier minted within the nanopublication. http://purl.org/np/RAYiQ_XN8D...#sig sig http://purl.org/nanopub/x/hasSignature has the signature (this is a literal) "lRFIp+jMXN7pqDRainfW71AuyLi4cVFt8ZvoMR5clLoWFTaXX1LEH2pt0aytnz9toAiRFZtrHAplknp7vYju0u2HrXP7jlJnvS27+V0z+g6r+vLg8+Y22LbnIN9YVs8TdCRy0vhVgnKqLpYdxI3QWOybFzw6BO9h7zWPpEETV9M=" .

This is the identifier for this whole nanopublication. http://purl.org/np/RAYiQ_XN8D... this nanopublication http://purl.org/dc/terms/creator creator https://orcid.org/0000-0002-1267-0234 Tobias Kuhn .

Tobias Kuhn, (undated)

References

Raw

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