assertion
Full identifier: http://purl.org/np/RA59XSqRVPk2FrSKMfCxyHV_NVcPGekpLer0BEIbmIb74#assertion
Searching for classes... 
Searching for instances...
Searching for templates...
Minted in Nanopublication
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#association
This association
http://www.w3.org/2000/01/rdf-schema#label
has label
(this is a literal)
"While alcohol induces an increase of dopamine, ondansetron reduces the release of the neurotransmitter by blocking the 5-HT3 receptors. Several studies investigated the effectiveness of ondansetron by dividing alcoholic individuals into two subgroups based on their genotype for the promoter region of the SLC6A4 gene coding for the serotonin transporter (5-HTTLPR L/S polymorphism). The study showed that the patients with the LL genotype treated with ondansetron responded better in terms of alcohol amount and days of abstinence, compared to the other subgroups. Based on these results, researchers have further investigated genotype LL carriers, by analyzing the role of a functional polymorphism of the SLC6A4 gene (rs1042173 [T/G] SNP). The result was that individuals who carry both 5-HTTLPR LL polymorphism and rs1042173 TT polymorphism, treated with ondansetron at the dosage of 0.5 mg/die, present a more effective response to the drug. Unfortunately, the sample of this exploratory study was too small to be validated."
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#subject
has drug
https://identifiers.org/DRUGBANK:DB00904
DRUGBANK:DB00904
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#object
has disease
http://purl.obolibrary.org/obo/DOID_1574
DOID_1574
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#association
This association
https://w3id.org/biolink/vocab/relation
has relation
https://w3id.org/um/neurodkg/OffLabelIndication
An indication found in off-label drug uses
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#association
This association
https://w3id.org/biolink/vocab/publications
has publications
https://pubmed.ncbi.nlm.nih.gov/29912214
pubmed.ncbi.nlm.nih.gov/29912214
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
has type
http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement
association Statement
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#association
This association
http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate
has predicate
https://w3id.org/biolink/vocab/treats
treats
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#association
This association
https://w3id.org/biolink/vocab/provided_by
is provided by
https://w3id.org/um/NeuroDKG
NeuroDKG
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA59XSqRVP...#association
association
https://w3id.org/biolink/vocab/has_population_context
has_population_context
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA59XSqRVP...#context
context
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA59XSqRVP...#context
context
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
type
https://w3id.org/biolink/vocab/Cohort
Cohort
.
This is a local identifier that was minted when the nanopublication was created.
http://purl.org/np/RA59XSqRVP...#context
context
http://www.w3.org/2000/01/rdf-schema#label
label
"adults"
.
This is the identifier for the assertion of this nanopublication.
http://purl.org/np/RA59XSqRVP...#assertion
The assertion above
http://www.w3.org/ns/prov#generatedAtTime
generatedAtTime
(this is a literal)
"2021-08-26T09:18:24.960707"
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RA59XSqRVP...
This nanopublication
links to the assertion template that was used to create this nanopublication
https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate
was created from the assertion template
http://purl.org/np/RAhNHZw6Ur...
RAhNHZw6Ur
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#sig
sig
http://purl.org/nanopub/x/hasSignatureTarget
has as target
This is the identifier for this whole nanopublication.
http://purl.org/np/RA59XSqRVP...
this nanopublication
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#sig
sig
http://purl.org/nanopub/x/hasAlgorithm
has the algorithm
(this is a literal)
"RSA"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#sig
sig
http://purl.org/nanopub/x/hasPublicKey
has the public key
(this is a literal)
"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB"
.
This is a local identifier minted within the nanopublication.
http://purl.org/np/RA59XSqRVP...#sig
sig
http://purl.org/nanopub/x/hasSignature
has the signature
(this is a literal)
"HKO/6/WbH6tUaC0vBhS/q+EAWDcX+6Z11YP0zdctz1Vbb7g1MLWld46IbtKKqoEuI30DM9aK5UNbjEHrEkYaXal8+yk+OGuQi/5bAy/7i3ceSzsUT5sre6FuZJa/6KYJxDwW/tdYjcds8+F3hFttF+4/5FINgd33yqo4wLhfyrw="
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RA59XSqRVP...
this nanopublication
http://www.w3.org/ns/prov#generatedAtTime
generatedAtTime
(this is a literal)
"2021-08-26T09:18:24.960707"
.
This is the identifier for this whole nanopublication.
http://purl.org/np/RA59XSqRVP...
this nanopublication
http://www.w3.org/ns/prov#wasAttributedTo
wasAttributedTo
https://orcid.org/0000-0002-7641-6446
0000-0002-7641-6446
.
References