association

Full identifier: http://purl.org/np/RA59XSqRVPk2FrSKMfCxyHV_NVcPGekpLer0BEIbmIb74#association

Assigned to 1 class:

Minted in Nanopublication

 RA59XSqRVP comment approve/disapprove edit as derived nanopublication create new with same template

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA59XSqRVP...#association association https://w3id.org/biolink/vocab/has_population_context has_population_context This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA59XSqRVP...#context context .
This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA59XSqRVP...#context context http://www.w3.org/2000/01/rdf-schema#label label "adults" .
This is the identifier for this whole nanopublication. http://purl.org/np/RA59XSqRVP... This nanopublication links to the assertion template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate was created from the assertion template http://purl.org/np/RAhNHZw6Ur... RAhNHZw6Ur .
This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#sig sig http://purl.org/nanopub/x/hasSignatureTarget has as target This is the identifier for this whole nanopublication. http://purl.org/np/RA59XSqRVP... this nanopublication .
This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#sig sig http://purl.org/nanopub/x/hasAlgorithm has the algorithm (this is a literal) "RSA" .

0000-0002-7641-6446, 26 Aug 2021, 09:18:24 UTC

References

Nanopublication Part Subject Predicate Object Published By Published On
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
0000-0002-7641-6446
2021-08-26T09:18:24.960Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
While alcohol induces an increase of dopamine, ondansetron reduces the release of the neurotransmitter by blocking the 5-HT3 receptors. Several studies investigated the effectiveness of ondansetron by dividing alcoholic individuals into two subgroups based on their genotype for the promoter region of the SLC6A4 gene coding for the serotonin transporter (5-HTTLPR L/S polymorphism). The study showed that the patients with the LL genotype treated with ondansetron responded better in terms of alcohol amount and days of abstinence, compared to the other subgroups. Based on these results, researchers have further investigated genotype LL carriers, by analyzing the role of a functional polymorphism of the SLC6A4 gene (rs1042173 [T/G] SNP). The result was that individuals who carry both 5-HTTLPR LL polymorphism and rs1042173 TT polymorphism, treated with ondansetron at the dosage of 0.5 mg/die, present a more effective response to the drug. Unfortunately, the sample of this exploratory study was too small to be validated.
0000-0002-7641-6446
2021-08-26T09:18:24.960Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
0000-0002-7641-6446
2021-08-26T09:18:24.960Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
0000-0002-7641-6446
2021-08-26T09:18:24.960Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
0000-0002-7641-6446
2021-08-26T09:18:24.960Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
0000-0002-7641-6446
2021-08-26T09:18:24.960Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
0000-0002-7641-6446
2021-08-26T09:18:24.960Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
0000-0002-7641-6446
2021-08-26T09:18:24.960Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
association
0000-0002-7641-6446
2021-08-26T09:18:24.960Z

Raw

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